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Job ID :
59861BR
Location :
India - Bangalore
:
Job Description

Qualification

• Applicants should have a Masters with 5 + years experience or a PhD in the area of structural biology, biochemistry or biophysics integrated with cell biology, molecular biology, immunology or related fields. Experience in Structural biology is a must.

• GLP, GMP or any other certification in laboratory practices and EHS certification will be considered as a bonus

Responsibilities

  • Structure based design of antigens for antibody development – proteins, peptides, nucleotides etc.
  • Analysis of protein structures, peptide design and modifications
  • Solubility analysis, hydropathy plots, handling primary, secondary and tertiary protein structure.
  • Navigating through databases, handling various simulation softwares and analytics
  • Reviewing and evaluating various conjugation methodologies, carrier protein chemistries, haptens etc.
  • Involved in antigen production using various recombinant protein expression methodologies and bacterial, insect or mammalian cell culture systems
  • Antibody-antigen affinity analysis using SPR, Biacore etc.
  • Responsible for data integrity and accuracy.
  • Organizing data reviews and team meetings.
  • Presenting at national and international conferences.
  • Other functions such as writing technical protocols and filling out order forms.
  • Deliver high quality results according to project schedule in support of product commercialization during early feasibility, development and validation phases.

Skills

  • Well-versed in solubility analysis, primary, secondary and tertiary protein structure databases, softwares and analytics
  • Has extensive experience in crystallography and biophysical methods.
  • In depth knowledge of various conjugation methodologies, carrier protein chemistries, haptens etc.
  • Well-versed with recombinant protein expression methodologies using bacterial, insect and mammalian cell culture systems
  • Has extensive recombinant protein purification experience.
  • Experience in antibody-antigen affinity analysis using Biacore, Octet etc.
  • Well-versed in Structure-function analysis using site-directed mutagenesis or other strategies
  • GLP experience, documentation and automation
  • Publications in peer-reviewed journals would be a bonus. Good understanding of research projects using standard techniques and protocols.
  • Should be a good team player, ready to learn new techniques and innovative thinker.
  • Industry experience, bioinformatics and grant writing skills will be considered as a bonus.
  • Excellent organizational skills with attention to detail.


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