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Job ID :
Location :
US - California - Carlsbad
Job Description

Position Objective

Join the genome engineering revolution. This scientist will execute service based projects that primarily consist of genome engineering tool generation using the cutting edge cloning and genomic engineering techniques from the Thermo Fisher Scientific portfolio. This scientist will be expected to support projects and lead projects by leading cloning, sequencing, virus generation, and bio-informatics with an extensive use of automated liquid handling and laboratory information management systems. This scientist will act in a highly collaborative manner with the rest of the team through design, sequencing, analysis and large-scale manipulations of projects. Projects may include, but not be limited to, subcloning, plasmid preparations, in vitro transcription of RNA, lentiviral production; these projects may be driven by internal project design or by external collaborations.

Scope of Need

The successful individual will directly interact with R&D scientists and project management to execute a large number of specific project workplans. The scientist will be responsible for executing portions of these plans to meet agreed upon deliverables and timelines. These activities will require a high level of independence as well as the ability to work in a highly cooperative team.

This role will involve the following tasks:

  • DNA sequencing
    • Experience with Applied Biosystems capillary electrophoresis sequencing platforms
    • Experience with Ion Personal Genome Machine sequencing platforms
    • Experience performing varied sequencing analysis tasks
  • Bio-informatics
    • Experience using bio-informatic approaches and tools in applied situations:
      • Design of TALN or CRISPRs for genome engineering
      • Analysis of sequencing results following genome engineering
      • Analysis of gene sets and characterizing genes according to function, structure, pathway or disease
  • Liquid handling
    • Experience using liquid handling instrumentation, particularly for specific applications:
      • Preparing DNA input materials
      • Cloning DNA
      • Bacterial transformation, streaking, clone picking and expansion
      • Generating lentivirus
      • PCR
  • Information management
    • Experience using, designing, maintaining or administering LIMS systems to manage laboratory execution
    • Specifically, experience with Nautilus LIMS from Thermo Fisher Scientific will be a significant plus

This individual will also be expected to support and participate in R&D and project management meetings.

Capabilities and Competencies

This position requires the following capabilities and competencies:

  • Perform standard laboratory math calculations and solutions/media preparation
  • Proven experience:
    • Sequencing DNA from multiple sources and on multiple platforms
    • Various forms of PCR
    • Bioinformatics tools for design and analysis
    • Automation for cloning DNA (liquid handling, colony picking, DNA preparations)
    • Using LIMS to support laboratory execution
  • Ability to:
    • Observe deviations from the expected outcomes and trouble-shoot
    • Succeed with a moderate level of supervision and guidance
  • Strong teamwork orientation with demonstrable influence/interpersonal skills

This position will benefit from:

  • Proven sterile tissue culture technique

Minimum Requirements:

  • Bachelor’s degree or a master’s degree
  • 3+ years experience DNA sequencing
  • 3+ year experience in industry
  • 1+ year experience in automation for liquid handling / cloning

Preferred Requirements:

  • 1+ year experience with LIMS (esp. Nautilus)
  • 1+ years experience with bio-informatics for design and analysis


The Program Manager will interact with internal employees and management, as well as third party providers, and customers.

Working Conditions:

The vast majority of working time will be spent in a laboratory environment. Work will be focused around designing, ordering, cloning and otherwise manipulating DNA constructs and generating either lentivirus or in vitro transcribed RNA using automated liquid handling equipment and LIMS. Sequencing will also be critical throughout these tasks, using both capillary electrophoresis and the Ion Personal Genome machine.

Proven experience using automated liquid handlers and the use, design or support Nautilus LIMS to execute projects will be a significant plus compared to other candidates. Experience in industry and with tissue culture will also be considered significant differentiators. Some time will be spent at the desk recording laboratory activities appropriately in notebooks.

Must be capable of observing and adhering to lab safety standards and protocols. Flexibility in work schedule may be required: Early mornings, late evenings or weekend work may be required to maintain project schedules.

Critical to success in this position will be the individual’s ability to work independently on some projects and to provide collaboratively on others. This individual must be able to identify deviations from expected outcomes and participate in trouble-shooting those deviations and suggesting alternatives. Equally important will be the ability to work as part of a team in the laboratory (extended R&D team) as well as a broader cross-functional team (R&D, Project Management, Collaborator).

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.
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