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Job ID :
61210BR
Location :
Netherlands - Eindhoven|Switzerland - Basel|Switzerland - Zurich|United Kingdom - Cambridge
:
Job Description

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with revenues of $22B and 65,000 employees in 50 countries. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services – we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support.

Analytical Instruments Group - Materials & Structural Analysis Division

Our Thermo Scientific brand in the analytical instruments group offers customers in research, academic, industrial and applied markets a complete range of high-end analytical instruments as well as laboratory equipment, software and services. In the materials and structural analysis division we design, manu­facture, and support the broadest range of high-performance microscopy workflows that provide images and answers in the micro-, nano-, and picometer scales. Combining hardware and software expertise in electron, ion, FTIR, NIR, NMR UV/VIS and light microscopy with deep application knowledge in the materials science, life sci­ences, electronics, and natural resources markets. Our laboratory elemental analyzers use x-ray fluoresce (XRD), x-ray diffraction (XRD), and arc spark optical emission (EOS) techniques for precise analysis of bulk materials in the metals, cement, minerals and petrochemicals industries. Our material characterization instruments include rheometers and extruders that measure viscosity, elasticity, process ability and temperature related material changes of various materials. We also provide a range of elemental analysis instruments used in product development. Our worldwide team of 4,600 employees is dedicated to customers’ pursuit accelerating innovation and driving productivity.

The 2017 Nobel Prize in Chemistry: Cryo-electron microscopy explained

https://www.youtube.com/watch?v=026rzTXb1zw

How to make a Microscope

https://www.youtube.com/watch?v=9W6J_f4yVVg

Inside the FEI Titan Transmission Electron Microscope

https://www.youtube.com/watch?v=2wEmsDh_l_A

https://www.fei.com/life-sciences/large-volume-analysis/

POSITION SUMMARY

The purpose of the job of the Staff Scientist Medicinal Chemistry is to validate the value of cryo-EM for drug discovery.

The Staff Scientist Medicinal Chemistry will work in collaborations with pharma companies to create non-proprietary material for further business development. He will work in close collaboration with the Thermo Fisher cryo-EM applications specialists and the customers.

Responsibilities:

The Staff Scientist Medicinal Chemistry will be responsible for:

  • Identify cryo-EM value in drug discovery. Based on the various steps in drug discovery, analyze and identify where cryo-EM can add most value. Define how cryo-EM can contribute to a better, more efficient and more effective drug discovery process.
  • Set up collaborations. Set up collaborations with pharmaceutical companies and/or Contract Research Organizations to validate the hypotheses on cryo-EM in drug discovery.
  • Execute collaborations. Work with a multitude of disciplines and functions to execute collaborations towards pre-defined goals. Track and monitor progress. Report out within the organization to disseminate learnings effectively.
  • Develop collateral materials. Develop content for marketing materials that elucidates proven value of cryo-EM, to be used by business development and sales.
  • Drug discovery knowledge owner. Act as central point of expertise for drug discovery.

Minimum Qualifications:

This position is ideal for a candidate who has experience ad a medicinal chemist in the pharmaceutical industry, especially in the early drug discovery process. The successful candidate is an experienced professional who thrives in a dynamic team, can drive market development and enjoys being exposed to a constant variety of complex issues that need to be resolved. He/she is a great networker with strong influencing skills.

The successful candidate will possess the following combination of education and experience:

Education

PhD/Postdoc in synthetic organic chemistry with a good track record of publications

Experience

  • 5+ years of experience in the early drug discovery process, and a deep understanding of the complexities of interacting disciplines in that process. A good understanding of the decision points in drug discovery, and how various disciplines contribute.
  • Possessing advanced knowledge of medicinal chemistry principles, comprehensively understanding SR and familiar with all aspects of drug discovery.
  • Proficient in experimental design and laboratory equipment. Proficient in the use of analytical techniques for structural characterization. Experience with cryo-EM is an advantage but no necessity.
  • Good understanding of ADME, pharmacokinetics and optimal physiochemical properties.
  • Experience in structure based drug design.
  • Understanding of the various aspects of new technology adoption.
  • Experience in interacting with demanding customer groups, and the large variety of stakeholders involved in the decision processes

(Management) Skills

  • The ability to translate the drug discovery process in terms of technology requirements
  • The ability to steer projects in working with new technology
  • The ability to interact with a large number of different stakeholders, and balancing their needs while achieving set deliverables
  • Commercial savviness


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