Sr Research Scientist - Mass Spec

Work Schedule

Environmental Conditions

Job Description

Sr Research Scientist - Mass Spec - Sweden

Our PPD® Laboratory Services team has a direct impact on improving patient health through the expertise of scientists, industry thought-leaders and therapeutic experts. As the world leader in serving science, our laboratory professionals bring their commitment to accuracy and quality to deliver groundbreaking innovations.

Discover impactful work:

As Sr Research Scientist you will Be responsible for and conduct complex analytical development to create new analytical methods and enhances existing methods. Provide technical consulting to internal groups and clients about their programs. Provide technical guidance and mentorship in performing laboratory activities. Routinely act as the technical project leader for multiple projects, interact with multifunctional teams to provide technical project updates, reviews and evaluate data, write reports and protocols.

A Day in the life:

• Independently plans and performs the best scientific approach to develop analytical methods that meet the project’s objectives.
• Plan and perform experiments applying a deep understanding of protein mass spectrometry. This should include creating and implementing analysis such as peptide mapping for PTM analysis, top-down and bottom-up approaches, and quantitative methods such as iTRAQ/TMT labeling, label-free quantitation, thermal proteome profiling (TPP) for identification of drug targets and cross-linking mass spectrometry (XL-MS).
• Acts as on-site Subject Matter Expert (SME) for HRMS instrumentation, proteomics, qualitative analysis, and technology.
• Creates innovative technical options to obtain desired quality of analytical results, economics, and robustness in analytical applications. May also evaluate existing technical options to identify areas of improvement to achieve project objectives.
• Identify, develop, validate and implement novel analytical assays and new GMP/GLP-compliant methodologies for clinical and non-clinical studies. 
• Ability to lead client discussions regarding technical information exchanges and discussions of project status. Provides recommendations to clients on technical issues.
• Reviews protocols, project status reports, study reports and other project related technical documents.
• Presents posters and makes podium presentations at conferences.
• Leads in preparation and implementation of SOPs and quality systems, as well as developing innovative technology and in evaluating and implementing new capabilities.
• Reviews, interprets, and analyzes data for technical, quality and compliance to protocols, methods, SOPs, client criteria and Good Manufacturing Practices (GMP) or Good Laboratory Practices (GLP).
• Performs self and peer review of the data for accuracy and compliance with reporting requirements.
• Works on complex issues where analysis of situations or data requires an in-depth evaluation of variable factors.
• Has a wide range of experience, uses professional concepts and company objectives to resolve complex issues in creative and effective ways. 
• Determines methods and procedures on new assignments and may coordinate activities of other personnel (i.e., Team Lead).
• Exercises judgment in selecting methods, techniques and evaluation criteria for obtaining results.

Education and Experience:

• Bachelor’s degree, or equivalent and relevant formal academic / vocational qualification
• Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 10+ years).
• Deep understanding of protein mass spectrometry.

Knowledge, skills & Abilities:

• Candidates should have experience with nano-flow, capillary-flow, and micro-flow LC, and a range of separation techniques. Experience operating and maintaining high resolution-MS including but not limited to Thermo Orbitrap MS systems / Waters Synapt HDMS TOF systems / Bruker TIMS TOF series is expected.  Prior experience with Thermo Tribrid instruments is preferred.
• Candidate should have a strong working knowledge of commercial analytical software such as Proteome Discoverer, BioPharmaFinder, Xcalibur, Byos, Mascot, Peaks Studio or Bruker ProteoScape, scaffold, Progenesis QI and open-source software such as FragPipe, MaxQuant, MetaMorpheus, skyline (for targeted assay), as well as a basic understanding of Chromeleon and LIMS system.
• Expertise in data analytics tools such as R/python for analyzing high-dimenional data from proteomics experiments including pathway analysis.
• Ability to drive project timelines and deliverables while meeting Thermo/PPD’s internal quality and data integrity requirements.
• Candidate should show drive and hunger for applying scientific/technical/ GMP/GLP expertise to address complex R&D issues within a multifunctional project team.
• Demonstrated ability to author and/or review method development reports, technical documents, and peer-reviewed publications.
• Keen interest in identifying new scientific technologies and novel instrumentation which could potentially improve current workflow.
• Effective written and oral communication skills as well as presentation skills
• Full theoretical and hands-on understanding and knowledge of general chemistry and separation science
• Ability to independently review and understand project proposals/plan
• Proven ability in technical writing skills
• Ability to work in a collaborative work environment with a team

Work Environment

Thermo Fisher Scientific values the health and wellbeing of our employees. We support and encourage individuals to create a healthy and balanced environment where they can thrive.

Our Mission is to enable our customers to make the world healthier, cleaner and safer. Watch as our colleagues explain 5 reasons to work with us. As one team of 100,000+ colleagues, we share a common set of values - Integrity, Intensity, Innovation and Involvement - working together to accelerate research, solve complex scientific challenges, drive technological innovation and support patients in need. #StartYourStory with PPD, part of Thermo Fisher Scientific, where diverse experiences, backgrounds and perspectives are valued.